Clinical Pharmacology Management
Advanced DBA Program Specialization
Clinical Pharmacology Management
DBA Program
Overview
Clinical pharmacology is the investigation of medications in people. It is supported by the essential exploration of pharmacology, with included concentration the utilization of pharmacological standards and strategies in reality. ... In the research facility setting they examine biomarkers, pharmacokinetics, medicate digestion and hereditary qualities.
1) Effects of Renal Disease on Pharmacokinetic
Mechanisms of renal excretion of drugs
Effects of Impaired renal function on drug metabolism
Plasma protein binding of acidic drugs
2) Pharmacokinetic in Patients requiring renal replacement therapy
Kinetics of Intermittent Hemodialysis
Kinetics of continuous renal replacement therapy
3) Effects of Liver Disease on Pharmacokinetic
Hepatic Elimination of Drugs
Effects of Liver disease on Pharmacokinetic
Use of therapeutic drugs in Patents with Liver disease
4) No compartmental V/s Compartmental approaches to pharmacokinetic analysis
Estimating the kinetic parameters of the no compartmental model
Linear, constant coefficient compartmental models
5) Distribution Models of Drug Kinetics
The Intraperitoneal Administration of Agents
The Intraventricular Administration of Agents
Direct Interstitial Infusion of agents
6) Population Pharmacokinetic
Analysis of Pharmacokinetic Data
Population Pharmacokinetic
7) Drug Metabolism and transport
Additional effects on drug Metabolism
Phase II Bio transformations
Non – CYP Bio transformations
8) Methods of analysis of drugs and drug Metabolites
Choice of analytical Methodology
Chromatographic separations
Absorption and emission spectroscopy
Immunoaffinity Assays
9) Clinical Pharmacogenetics
Drug absorption
Drug distribution
Drug elimination
Mutations that influence drug receptors
10) Drug Interactions
Mechanisms of Drug Interactions
Prediction and Clinical Management of Drug Interactions
Clinical approach to drug Interactions
11) Biochemical Mechanisms of Drug Toxicity
Drug Induced Liver Toxicity
Mechanisms of other drug toxicities
12) Equilibrate and Concentrative drug transport Mechanisms
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